Featured Article

Harnessing Ecosystems of Translational Medicine:
Enterprise Architecture for Expeditionary Communities

Gary Edward Riccio, Ph.D. & Winston Patrick Kuo, DMSc

What are the connections between 21st century translational science and the transformational enterprises of 17th century Netherlands [1] or 15th century Venice [2]? The zeitgeist they share is expeditionary community that combines science, technology, and business to accelerate human initiative. In these earlier golden ages, entrepreneurs crossed boundaries with abandon. They did so to make connections with people whose resources and skills complemented their own. They forged improbably diverse communities that were necessary to survive on their journeys to new worlds and to thrive at their destinations. They existed within ecosystems, not industry verticals. They required funding as we do today but funding did not exist for most of their activities. The process was chaotic yet bounded. Individual initiative and self-interest were balanced by inescapable interdependence and formal systems for co-existence.

While there is much that leaders in government and industry can do to create structures and incentives for collaborative innovation, markers of success will be in the details of particular projects and systems and in the trust relationships that form among the participants. Innovation will occur in the intentional communities that coalesce around a shared intensity of purpose. Super connectors will play an important role in such communities by providing access to diversity, opportunities for legitimate peripheral participation, boundary objects that facilitate communication and coordination, and leadership in balancing initiative with accountability. These leaders will erase boundaries between business and science and, in doing so, they will expand the boundaries of the scientific community.

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A metaphor for Task organized teamwork and collective flow
(Photo courtesy of Melinda Merino)


Socio-technical Enterprise architecture for translational medicine



NIH Center for Translational Science
NIH Precision Medicine Initiative
NIH Implementation Science
Office of Science & Technology Policy
NASA Human Research Program
ONR Undersea Medicine Program
Naval Submarine Medical Research
USAF School of Aerospace Medicine
World Health Organization
Boston University Aging Well Institute
Boston Consulting Group Med Tech
McKinsey & Co Healthcare Systems

Topics of Conversation

Tweets about Medical and Heath
Tweets about Translational Medicine
Tweets about 'Omics
Tweets about Biomedical Engineering
Tweets about Wearable Sensing
Tweets about Medical Biometrics
Tweets about Public Health

Thought Leadership

Infographics and Images
World Health Organization on Aging Well
Aeronautics & Astronautics
Selective Open Innovation
Topics in Translational Medicine

NASA Translational Research
Omics in Systems Biology
Multi-Omics Integration
Science of Team Science
Manifesto for Reproducible Science
Machine Learning in Genomic Medicine
Precision Medicine Boards

Translational Medicine Journals

Translational Medicine
Translational Research
Clinical and Translational Science
Science Translational Medicine
American Journal for Translational Research
Clinical and Translational Medicine
Translational Medicine and Epidemiology
Annals of Translational Medicine
Translational Proteomics
New Horizons in Translational Medicine

Biomedical Engineering Journals

Biomedical Engineering
Neural Systems and Rehabilitation Engineering
Biomedical and Health Informatics
Reviews on Biomedical Engineering
Translational Engineering in Health & Medicine
Medical Imaging
Computational Biology and Bioinformatics
Computational Imaging
Biomedical Circuits and Systems
Life Sciences Letters