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Situated Precision Health in the Smart Medical Home:

Insight and Innovation from NASA’s Metascience

Gary Edward Riccio, Ph.D.

Science Program Management in NASA’s Human Research and Technology Development is relevant to a broader strategic transformation in research on healthcare. There is an opportunity and a challenge to harness the potential scientific knowledge transfer and associated technology transfer. In response to this challenge, I have engaged leaders in NASA’s human research to address what it would mean for such scientific strategy, in and of itself, to be scientific. I consider two unique and essential attributes of the associated science of science (metascience): scientific method and scientific community. I argue that meta-scientific progress in any approach to translational research for human health and wellness requires participation of technical, operational and programmatic peers from outside a single community such as human health and performance research at NASA. I thus introduce specific meta-scientific constructs and evidence from NASA and business scholarship that are relevant to mega-trends in healthcare writ large.

The article is organized in three major sections: (a) making metascience matter in public-private collaboration, (b) need for NASA’s demand-side innovation, and (c) combinatorial scientific and clinical paradigms. This provides a foundation for collaboration that can stimulate development of meta-scientific communities, defragment demand for solutions, and achieve a more coherent strategic approach to integration and development of a diversity of capabilities including but not limited to technology. I conclude with six meta-scientific principles from NASA that can transform research in healthcare through continual experimentation in a smart medical home. A companion article, Bringing NASA’s Metascience Down to Earth, builds on this foundation to make recommendations for development of new scientific and clinical paradigms that aggregate heterogeneous sources of data for innovation in lifestyle interventions in a smart medical home as well as lifespan approaches to precision brain health.

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A metaphor for Task organized teamwork and collective flow
(Photo courtesy of Melinda Merino)

 
 
 
 

Ecosystems

NIH Center for Translational Science
NIH Precision Medicine Initiative
NIH Implementation Science
NSF-NIH I-Corps
Office of Science & Technology Policy
NASA Human Research Program
ONR Undersea Medicine Program
Naval Submarine Medical Research
USAF School of Aerospace Medicine
World Health Organization
Boston University Aging Well Institute
Boston Consulting Group Med Tech
McKinsey & Co Healthcare Systems


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World Health Organization on Aging Well
Aeronautics & Astronautics
Selective Open Innovation
Topics in Translational Medicine

NASA Translational Research
Omics in Systems Biology
Multi-Omics Integration
Science of Team Science
Manifesto for Reproducible Science
Machine Learning in Genomic Medicine
Precision Medicine Boards


Translational Medicine Journals

Translational Medicine
Translational Research
Clinical and Translational Science
Science Translational Medicine
American Journal for Translational Research
Clinical and Translational Medicine
Translational Medicine and Epidemiology
Annals of Translational Medicine
Translational Proteomics
New Horizons in Translational Medicine


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Life Sciences Letters